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SLU-PP-332 – The idea that a pill could replace adequate exercise and healthy nutrition seems like the stuff of science fiction, but according to scientists at Washington University, a new pill really could prevent heart disease, dementia, and even build more muscle, by mimicking the effects of being active. Here’s what you need to know.
Scientists have created a compound called SLU-PP-332, and it works by activating specific proteins that are usually called upon by exercise. So far, experiments have been successful in rodent cells and the breakthrough might potentially result in future human applications that could make the population fitter and less likely to succumb to age or obesity related conditions such as diabetes and heart failure.
The theory is that a drug able to replicate the effects of exercise could stave off muscle atrophy and weakness, and slow down or prevent the emergence of cancers and other ailments.
But if you are thinking that a new ‘super’ pill could be an excuse to cancel your gym subscription, experts say you shouldn’t throw in the towel. “We cannot replace exercise; exercise is important on all levels,” said Bahaa Elgendy, the project’s principal investigator in a YouTube Q&A. “If I can exercise, I should go ahead and get the physical activity. But there are so many cases in which a substitute is needed.”
The SLU-PP-332 “Fitness Pill” Resists Muscle Fatigue
The researchers presented their results at the spring meeting of the American Chemical Society (ACS) this week and according to a press release, the metabolic changes associated with exercise kick off with the activation of specialized proteins known as estrogen-related receptors (ERRs), After around a decade of work, Elgendy and his colleagues developed a compound named SLU-PP-332, and it activates all three forms of ERR, including the most challenging target; ERRα.
This type of ERR regulates exercise-induced body adaptations and other important physiological processes in the muscles.
In experiments with mice, the team found that this compound increased a fatigue-resistant type of muscle fiber wihtout them doing any exercise, and also improved the animals’ endurance when they ran on a rodent treadmill. It goes without saying that it is early days for this potential ‘super pill,’ but if it can successfully translated to human use, it could have limitless potential for those who can’t exercise due to physical challenges, not to mention the potential buzz it could create in the world of supplements.
The new compound, developed and tested by a University of Florida professor of pharmacy and his colleagues, leads obese mice to lose weight by convincing the body’s muscles that they are exercising more than they really are, boosting the animals’ metabolism.
It also increases endurance, helping mice run nearly 50% further than they could before. All without the mice lifting a paw.
The drug belongs to a class known as “exercise mimetics,” which provide some of the benefits of exercise without increasing physical activity.
The new treatment is in the early stages of development but could one day be tested in people to treat diseases like obesity, diabetes, and age-related muscle loss. The research comes as drugs like Ozempic have provided a breakthrough in reducing appetite, helping treat these metabolic diseases.
But the new drug, known as SLU-PP-332, doesn’t affect appetite or food intake. Nor does it cause mice to exercise more. Instead, the drug boosts a natural metabolic pathway that typically responds to exercise.
In effect, the drug makes the body act like it is training for a marathon, leading to increased energy expenditure and faster metabolism of fat in the body.
“This compound is basically telling skeletal muscle to make the same changes you see during endurance training,” said Thomas Burris, a professor of pharmacy at UF who led the recent research into the new drug.
“When you treat mice with the drug, you can see that their whole body metabolism turns to using fatty acids, which is very similar to what people use when they are fasting or exercising,” Burris added. “And the animals start losing weight.”
With a team of researchers at Washington University in St. Louis and St. Louis University, Burris published his findings Sept. 22 in the Journal of Pharmacology and Experimental Therapeutics.
The new drug targets a group of proteins in the body known as ERRs, which are responsible for activating some of the most important metabolic pathways in energy-gobbling tissues like muscles, the heart, and the brain.
The ERRs are more active when people exercise, but they have proven difficult to activate with drugs.
In another paper published in March, the researchers reported that they had successfully designed SLU-PP-332 to boost activity of the ERRs. They also observed that the compound allowed normal-weight mice to run for 70% longer and 45% further than mice not receiving the drug.
In their latest research, the team tested the drug on obese mice. Treating obese mice twice a day for a month caused them to gain 10 times less fat than untreated mice and lose 12% of their body weight. Yet the mice kept eating the same amount of food and didn’t exercise any more.
“They use more energy just living,” Burris said.
So far, the drug hasn’t generated any severe side effects. The next step in developing SLU-PP-332 into a drug candidate will be to refine its structure, ideally making it available as a pill instead of an injection.
Then the drug would be tested for side effects in more animal models before making the jump to human trials.
Other exercise mimetics have been tested, but none have made it to market, in part because it takes years to develop a new drug. Targeting obesity, specifically, with a drug has historically been difficult because of how complex obesity is. That was until Ozempic, Wegovy, and Mounjaro, developed to treat diabetes, also caused people to lose weight.
This development led to a surge of interest, research, and funding for drugs that could treat these metabolic diseases through different biological pathways.
Burris says the greatest hope for the new drug might be in maintaining muscle mass during weight loss – which often threatens lean muscle mass – or during aging, when the body naturally responds less strongly to exercise. But it will take more research to understand the drug’s full potential.
“This may be able to keep people healthier as they age,” Burris said.
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